flowchart TD
A["
Neural Tube Defects"]
style A fill:#331D2C,stroke:#331D2C
A --> B["
Cranial"]
style B fill:#3F2E3E,stroke:#3F2E3E
B --> B1["
AnencephalyLethal anomaly"]
style B1 fill:#3F2E3E,stroke:#3F2E3E
B --> B2["
EncephaloceleIntracranial structures protrude through a skull defectUsually associated with other NTDs"]
style B2 fill:#3F2E3E,stroke:#3F2E3E
B --> B3["
IniencephalyAnomaly of the cranio-cervical spine"]
style B3 fill:#3F2E3E,stroke:#3F2E3E
A --> C["
Spinal"]
style C fill:#A78295,stroke:#A78295
C --> C1["
Open"]
style C1 fill:#A78295,stroke:#A78295
C1 --> C1a["
MyelomeningoceleProtrusion of the neural placode behind the skin surfaceExpansion of subarachnoid space"]
style C1a fill:#A78295,stroke:#A78295
C1 --> C1b["
MyeloschisisPlacode remains at the skin levelSpinal canal directly exposed"]
style C1b fill:#A78295,stroke:#A78295
C --> C2["
ClosedNot usually associated with cranial alterationsAlpha-fetoprotein not elevated"]
style C2 fill:#A78295,stroke:#A78295
C2 --> C2a["
Subcutaneous Mass?"]
style C2a fill:#A78295,stroke:#A78295
C2a --> D1["
Yes"]
style D1 fill:#A78295,stroke:#A78295
D1 --> D1a["
Lipomyelomeningocele and LipomyeloschisisLipomatous mass"]
style D1a fill:#A78295,stroke:#A78295
D1 --> D1b["
MeningoceleHerniation of meninges and skin"]
style D1b fill:#A78295,stroke:#A78295
D1 --> D1c["
MyelocystoceleHerniation of cord with dilated ependymal canal"]
style D1c fill:#A78295,stroke:#A78295
C2a --> D2["
No"]
style D2 fill:#A78295,stroke:#A78295
subgraph Simple
direction LR
D2a1["
Intradural / filum terminale lipoma"]
style D2a1 fill:#A78295,stroke:#A78295
D2a2["
terminal ventricle"]
style D2a2 fill:#A78295,stroke:#A78295
D2a3["
dermal sinus"]
style D2a3 fill:#A78295,stroke:#A78295
end
subgraph Complex
direction LR
D2b1["
Neurenteric cyst"]
style D2b1 fill:#A78295,stroke:#A78295
D2b2["
diastematomyelia"]
style D2b2 fill:#A78295,stroke:#A78295
D2b3["
caudal regression syndrome"]
style D2b3 fill:#A78295,stroke:#A78295
D2b4["
segmental spinal dysgenesis"]
style D2b4 fill:#A78295,stroke:#A78295
end
D2 --> Simple
D2 --> Complex